TLV BioBank - The Institutional Biobank

At Tel Aviv Medical Center - Ichilov

About Us
TLV BioBank is a hospital-based biomedical resource that collects and stores biological samples along with de-identified clinical, pathological, and demographic data from patients at Tel Aviv Sourasky Medical Center.
It serves as a centralized infrastructure supporting research aimed at improving the understanding, diagnosis, and treatment of a wide range of diseases. The resource is accessible to approved researchers from academic institutions and industry, under ethical and regulatory oversight.


Team

Katia Pozyuchenko, M.Sc

Head of TLV BioBank
katiap@tlvmc.gov.il

Available Samples

Our biobank team collects a variety of human biospecimens, either retrospectively or prospectively, depending on the study design and clinical setting.

  • Body fluids: blood, bone marrow aspirates, synovial fluid and other clinically obtained fluids
  • Tissue samples: tumor and adjacent non-tumor tissue, including FFPE (formalin-fixed, paraffin-embedded)
  • Other sample types: stool, saliva, additional materials collected according to specific protocols

Samples are collected from patients with a range of medical conditions, including malignant and benign tumors, rheumatologic diseases, and other clinical backgrounds. The biobank also includes samples from healthy donors without a specific diagnosis, collected during clinical care.

 

TLV BioBank continues to expand its collections and is part of the hospital’s broader efforts to advance translational research and precision medicine.

Access and Collaboration

Researchers from within the hospital, external academic institutions, and the life sciences industry are welcome to request access to the biobank’s resources.

Ethical approval from the Institutional Helsinki Committee (IRB) is required in order to use samples and associated data for research purposes. In such applications, researchers may request for exemption from seeking re-consent, as all donors have already signed the biobank’s informed consent form.

We are available to assist in assessing feasibility and guiding researchers through the request process.

Information & Resources

  1. Patient Recruitment – The BioBank team recruits sample donors in pre-op clinics and during follow-up examinations at Ichilov Hospital.
  2. Informed Consent – BioBank research coordinators review informed consent form with each patient, explaining the overall purpose of the BioBank, how samples are collected, and how samples impact medical research.
  3. Sample Collection – On the day of the operational procedure, the BioBank team collects and transfers tissue samples to the Institute of Pathology where remaining tissue not needed for diagnosis is considered for storage.
  4. Sample Preservation – BioBank samples are stored for 25 years in liquid nitrogen freezers.

Yes. The Biobank team can provide prospective collection of fresh tissues and blood samples for research.

Contact TLV BioBank

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Highlight Publications

Proinflammatory macrophages promote multiple myeloma resistance to bortezomib therapy
Beyar-Katz O, Magidey K, Reiner-Benaim A, Barak N, Avivi I, Cohen Y, Timaner M, Avraham S, Hayun M, Lavi N, Bersudsky M, Voronov E, Apte RN, Shaked Y.
Mol Cancer Res. 2019 Nov;17(11):2331-2340

Patient-derived Tumor Spheroid Cultures as a Promising Tool to Assist Personalized Therapeutic Decisions
Hofmann S, Cohen-Harazi R, Maizels Y, Koman I.
BioRxiv. 2021 Jan 1;2021.06.26.450027

The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, Meltser A, Douglas GM, Kamer I, Gopalakrishnan V, Dadosh T, Levin-Zaidman S, Avnet S, Atlan T, Cooper ZA, Arora R, Cogdill AP, Khan MAW, Ologun G, Bussi Y, Weinberger A, Lotan-Pompan M, Golani O, Perry G, Rokah M, Bahar-Shany K, Rozeman EA, Blank CU, Ronai A, Shaoul R, Amit A, Dorfman T, Kremer R, Cohen ZR, Harnof S, Siegal T, Yehuda-Shnaidman E, Gal-Yam EN, Shapira H, Baldini N, Langille MGI, Ben-Nun A, Kaufman B, Nissan A, Golan T, Dadiani M, Levanon K, Bar J, Yust-Katz S, Barshack I, Peeper DS, Raz DJ, Segal E, Wargo JA, Sandbank J, Shental N, Straussman R.
Science. 2020 May 29;368(6494):973-980.

Personalized Ubiquitination Signatures for Predicting Response to Proteasome Inhibitor-Based Therapy of MM Patients
Tsubery H, Lerman G, Kronenfeld G, Sela I, Merbl Y, Itzhaki-Alfia A, Trestman S, C Cohen Y, Avivi I
Blood. 2019 Nov; 134 (Supplement_1): 3371.