Cardiovascular Research laboratory

Our Vision


Translational-oriented research of cardiac pathology

Our Team

  • Prof. Gad Keren, Lab PI, Head of the Cardiovascular Research lab;Cardiology, Sackler School of Medicine.
  • Dr. Michal Entin-Meer, Lab manager

  • Sivan Oren, PhD
  • Yuval Kleinberg, MsC

  • Einat Bigelman-PhD student
  • Lena Cohen- PhD student

Research

at the peri-infarct zone 3 days post myocardial infarction

The potential involvement of the TRPV2 Ca2+channel in cardiac pathology, oncology and cardiac-oncology. A TRPV2 blocking agent is being developed in collaboration with the BLAVATNIK center for drug discovery.

are highly involved in mediating cardiac pathology and progression to reno-cardiac syndrome following cardiac injury

Highlighted Publications

Potential roles in cardiac physiology and pathology of the cation channel TRPV2 expressed in cardiac cells and cardiac macrophages: a mini-review.

Entin-Meer M, Keren G. Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H181-H188.

Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody.

Cohen L, Sagi I, Bigelman E, Solomonov I, Aloshin A, Ben-Shoshan J, Pasmanik-Chor M, Rozenbaum Z, Keren G, Entin-Meer M. PLoS One. 2020 Oct 22;15(10):e0241419.

Pathological presentation of cardiac mitochondria in a rat model for chronic kidney disease

lman E, Cohen L, Aharon-Hananel G, Levy R, Rozenbaum Z, Saada A, Keren G, Entin-Meer M. PLoS One. 2018 Jun 11;13(6):e0198196.

 

Downregulated Expression of TRPV2 in Peripheral Blood Cells following Acute Myocardial Infarction Is Inversely Correlated with Serum Levels of CRP and Troponin I.

Rozenbaum Z, Cohen L, Bigelman E, Shacham Y, Keren G, Entin-Meer M.Cardiology. 2018;139(3):169-174. 

Increased CD11b+ cells and Interleukin-1 (IL-1) alpha levels during cardiomyopathy induced by chronic adrenergic activation

Ben-Shoshan J, Jubran A, Levy R, Keren G, Entin-Meer M.Isr Med Assoc J. 2017 Sep;19(9):570-575.

TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages

Entin-Meer M, Cohen L, Hertzberg-Bigelman E, Levy R, Ben-Shoshan J, Keren G.PLoS One. 2017 May 8;12(5):e0177132. doi: 10.1371/journal.pone.0177132. eCollection 2017.