Center for the Study of Movement

Cognition and Mobility

Our Vision

As the baby boomers age, the number of adults who suffer from frequent falls, gait disorders, cognitive impairment, dementia, and other neurological diseases continues to increase dramatically. New understandings and therapeutic approaches are needed. Our research aims to improve the personalized treatment of age-related movement, cognition, and mobility disorders and to alleviate the burden associated with them. We leverage a combination of clinical, engineering, and neuroscience expertise:

  • To gain new understandings into the physiologic and pathophysiologic mechanisms that contribute to cognitive and motor function, the factors that influence these functions, and their changes with aging and disease (e.g., Parkinson’s disease, Alzheimer’s).
  • To develop new methods and tools for the early detection and tracking of cognitive and motor decline.
  • To develop and evaluate novel methods for the prevention and treatment of gait, falls, and cognitive function.

Our Team

  • Prof. Jeff Hausdorff, Director, Department of Physical, Sackler Faculty of Medicine, TAU; Sagol School of Neuroscience, TAU
  • Prof. Anat Mirelman, Associate Director
  • Meital Zahavi Schreiber, Lab Manager

  • Inbal Maidan
  • Talia Herman
  • Eran Gazit
  • Marina Brozgol
  • Pablo Cornejo Thumm
  • David Buzaglo
  • Keren Cochavi
  • Nimrod Geffen
  • Shahar Yehezkyahu
  • Amit Salomon ‎

  • Ira Galperin
  • Dafna Schwartz
  • Assaf Zadka
  • Miriam Urbach
  • Maya Thatcher
  • Galia Shaham
  • Yonatan Brand
  • Shlomit Haim
  • Or Engelhardt

  • Tal Reches
  • Aner Weiss
  • Natalie Ganz
  • Ayala Saban
  • Leor Gruendlinger
  • Inbar Hillel
  • Shirley Shema
  • Moran Dorman
  • Mor Frank
  • Ilan Kurz
  • Hagar Brandt
  • Tal Freedman
  • Shiran Shustak
  • Ariel Tankus
  • Meir Plotnik
  • Yoav Beck;
  • Keren Rosenberg-Katz
  • Yael Jacob

Research

This multi-center study is being conducted with the input of 34 centers is designed to connect digital mobility assessment to clinical outcomes for regulatory and clinical endorsement. Technical and clinical validation is being performed in five clinical cohorts (e.g., Parkinson’s disease, multiple sclerosis, post-hip fracture).

Pathologies of Alzheimer's disease (AD)

In conjunction with researchers at Rush University, this work examines the relationships between AD pathologies and related disorders in brain, brainstem, and spinal cord to gait.

Using Reference Ability Neural Networks

In collaboration with researchers at Columbia University, this research aims to generate new insights into the neural basis of the most important and central features of cognitive aging and its association with changes in gait and mobility

Digital wearable walking aid for freezing of gait

The goal of this work is to evaluate the effects of intelligent, Smartphone-based cueing on freezing of gait in patients with Parkinson’s disease.

home-based gait training for people with Parkinson's disease

This research aims to assess the feasibility of providing tele-rehabilitation over an extended period to people with Parkinson’s disease using wearable devices and a dedicated Smartphone app

in health status among people with multiple sclerosis using wearables

Working with Owlytics Healthcare, we are developing new markers of motor function and health status based on data collected from a SmartWatch in people with multiple sclerosis.

In collaboration with researchers at Columbia University, we are developing measures of physical activity, gait and chorea from a wrist-worn sensor in people with Huntington’s disease.

This work aims to evaluate the potential of using non-invasive brain stimulation to improve gait and cognitive function among people with Parkinson’s disease.

From The Press

Highlighted Publications

Quantification of Daily-Living Gait Quantity and Quality Using a Wrist-Worn Accelerometer in Huntington’s Disease.

Keren K, Busse M, Fritz NE, Muratori LM, Gazit E, Hillel I, Scheinowitz M, Gurevich T, Inbar N, Omer N, Hausdorff JM, Quinn L

Front Neurol. 2021;12:719442

Impaired Inhibitory Control During Walking in Parkinson’s Disease Patients: An EEG Study.

Sosnik R, Danziger-Schragenheim S, Possti D, Fahoum F, Giladi N, Hausdorff JM, Mirelman A, Maidan I

J Parkinsons Dis. 2021

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial.

Manor B, Dagan M, Herman T, Gouskova NA, Vanderhorst VG, Giladi N, Travison TG, Pascual-Leone A, Lipsitz LA, Hausdorff JM.

Mov Disord. 2021;36:2693-2698.

A multimodal approach using TMS and EEG reveals neurophysiological changes in Parkinson’s disease.

Maidan I, Zifman N, Hausdorff JM, Giladi N, Levy-Lamdan O, Mirelman A.

Parkinsonism Relat Disord. 2021;89:28-33.

Targeted tDCS Mitigates Dual-Task Costs to Gait and Balance in Older Adults.

Zhou J, Manor B, Yu W, Lo OY, Gouskova N, Salvador R, Katz R, Cornejo TP, Brozgol M, Ruffini G, Pascual-Leone A, Lipsitz LA, Hausdorff JM.

Ann Neurol. 2021;90:428-439.

Detecting Sensitive Mobility Features for Parkinson’s Disease Stages Via Machine Learning.

Mirelman A, Ben Or FM, Melamed M, Granovsky L, Nieuwboer A, Rochester L, Del DS, Avanzino L, Pelosin E, Bloem BR, Della CU, Cereatti A, Bonato P, Camicioli R, Ellis T, Hamilton JL, Hass CJ, Almeida QJ, Inbal M, Thaler A, Shirvan J, Cedarbaum JM, Giladi N, Hausdorff JM.

Mov Disord. 2021;36:2144-2155.

Distinct cortical thickness patterns link disparate cerebral cortex regions to select mobility domains.

Maidan I, Mirelman A, Hausdorff JM, Stern Y, Habeck CG

Sci Rep. 2021;11:6600.

Combining transcranial direct current stimulation with a motor-cognitive task: the impact on dual-task walking costs in older adults.

Schneider N, Dagan M, Katz R, Thumm PC, Brozgol M, Giladi N, Manor B, Mirelman A, Hausdorff JM.

J Neuroeng Rehabil. 2021;18:23.

Body-Worn Sensors for Remote Monitoring of Parkinson’s Disease Motor Symptoms: Vision, State of the Art, and Challenges Ahead.

Del DS, Kirk C, Yarnall AJ, Rochester L, Hausdorff JM.

J Parkinsons Dis. 2021;11:S35-S47.

Tai Chi training’s effect on lower extremity muscle co-contraction during single- and dual-task gait: Cross-sectional and randomized trial studies.

Wayne PM, Gow BJ, Hou F, Ma Y, Hausdorff JM, Lo J, Rist PM, Peng CK, Lipsitz LA, Novak V, Manor B.

PLoS One 2021. ;16:e0242963.

Sensor-Based and Patient-Based Assessment of Daily-Living Physical Activity in People with Parkinson’s Disease: Do Motor Subtypes Play a Role?

Galperin I, Herman T, Assad M, Ganz N, Mirelman A, Giladi N, Hausdorff JM.

Sensors (Basel). 2020 ;20.

Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition.

Mahinrad S, Shownkeen M, Sedaghat S, Yaffe K, Hausdorff JM, Lloyd-Jones DM, Gorelick PB, Sorond FA

Alzheimers Dement. 2021;17:745-754.

 Automatic Quantification of Tandem Walking Using a Wearable Device: New Insights Into Dynamic Balance and Mobility in Older Adults.

Ganz N, Gazit E, Giladi N, Dawe RJ, Mirelman A, Buchman AS, Hausdorff JMJ Gerontol A Biol Sci Med Sci. 2021;76:101-107.

Dopaminergic therapy and prefrontal activation during walking in individuals with Parkinson’s disease: does the levodopa overdose hypothesis extend to gait?

Dagan M, Herman T, Bernad-Elazari H, Gazit E, Maidan I, Giladi N, Mirelman A, Manor B, Hausdorff JM.

J Neurol. 2021;268:658-668.

Changes in the EEG spectral power during dual-task walking with aging and Parkinson’s disease: initial findings using Event-Related Spectral Perturbation analysis.

Possti D, Fahoum F, Sosnik R, Giladi N, Hausdorff JM, Mirelman A, Maidan I.

J Neurol. 2021;268:161-168.

Gait and cognitive abnormalities are associated with regional cerebellar atrophy in elderly fallers – A pilot study.

Droby A, El Mendili MM, Giladi N, Hausdorff JM, Maidan I, Mirelman A.

Gait Posture. 2021;90:99-105.

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