Our Vision
Cancer is not an isolated process and its development is tightly associated with endocrine and metabolic changes in the body. As a lab sitting next to the Oncology Division, the bench and bedside are constantly intertwined. Therefore, we are not only focused on the patient's tumor, but know that the cancer disease is affected by many other factors. By investigating the complex interactions between the tumor, the received treatments and basic patient's characteristics, we are able to decipher novel endocrine aspects of malignancy and gain new insights into the development of cancer. This in turn uncovers vulnerabilities of the cancer and may aid in the development of novel treatments.
Our Team
- Ido Wolf Lab PI, Dept. of Internal Medicine
- Tami Rubinek Lab PI, Dept. of Internal Medicine
- Keren Marenbakh-Lamin, PhD, Lab PI
- Hagai Ligumsky MD, PhD
- Fadi Rizqa, MSc
- Arkadi Hesin, PhD student
- Lotem Zinger, PhD student
- Inbal Greenberg, MD/PhD student
- Shani Journo, PhD student
- Marwa Taya, PhD student
- Marana Abboud, MSc student
- Sivan Fuchs, MSc student
- Shai Bar-Shira
Researchers
- Lilach Abramovitz, PhD
- Ayelet Orbach-Shabtay, PhD
Students
- Smadar Levanon, MSc
- Shiri Shahmoon, PhD
- Tammi Rubinstein, MD, PhD
- Ira Lojkin, PhD
- Riva Shmulevich, PhD
- Inbal Reuveni, MSc student
- Adi Elazar, MSc
Madaei Yesod
- Gil Har Zahav
- Anton Wol
MD thesis
- Shira Hasson, in honor
- Eliya Shachar, in honor
- Tal Eitan, in honor
- Bar Davidov, in honor
- Tomer Boldes, in honor
Research
a link between longevity, metabolism and cancer
Aging and cancer development are tightly connected. The hormone klotho plays an important role in human aging. Our lab discovered its role as a tumor suppressor gene. It is silenced in cancer tissues and klotho’s re-expression in cancer cells inhibits their growth. Further analysis revealed klotho as a modulator of signaling pathways, especially those that regulate metabolic pathway.
Currently, we are focusing on discovery of its putative receptor and developing novel klotho-based treatments against cancer.
mutations in breast cancer
Our lab was the first to discover mutations in ESR1 that confer resistance to hormonal therapies in >40% of patients with metastatic breast cancer. We are trying to find the relationship between mutations and a more aggressive disease as well as finding new treatment strategies.
We are tackling the role of specific mutations in mediating homing of cancer cells to specific organs. Using large patients’ databases and advanced bioinformatics we identify genes and pathways that coax homing of cancer cells to specific organs. Specifically, we are focusing on the relationship between the mutations and metabolic pathways.
From The Press
- Dr. Ido Wolf-Biography
- 'Achilles heel' of pancreatic cancer
- Technology aims to make more livers available for transplantation
- Cancer - What are the chances of getting sick and what are the chances of recovering
- Shedding light on liver metastasis in pancreatic cancer
- Israeli breakthrough in dealing with pancreatic cancer
Highlight Publications