1. ELEVATED PLASMA LEVEL OF FACTOR VIII AMONG WOMEN WITH SEVERE PREGNANCY COMPLICATIONS

Objective: Recently it has been shown that elevated plasma levels of factor VIII are associated with an increased risk of thromboembolism (N engl J Med 2000; 343:457-62). The aim of this study was to investigate the prevalence of elevated factor VIII levels in women with severe complications of pregnancy.

Study Design: The study group included 41 women who had severe pregnancy complications: severe preeclampsia (n=15), stillbirth (n=13), severe IUGR (n=12) and abruptio placentae (n=1). The control group included 30 healthy women who had had at least one normal pregnancy. All women were tested few months after delivery for mutations of factor V Leiden, prothrombin gene, methylenetetrahydrofolate reductase, for deficiencies of protein S, C and antithrombin III, anticardiolipin antibodies, lupus anticoagulant and factor VIII plasma level. Women who used oral contraceptive pill or had known underlying disorders were excluded.

2. Doppler Measurement in Mid-Trimester Severe Intrauterine Growth Restriction Associated with Thrombophilia

3. THE PREVALENCE OF INHERITED THROMBOPHILIAS IN PRETERM INFANTS WITH PERIVENTRICULAR LEUKOMALACIA.

Objective: Periventricular leukomalacia (PVL) is an ischemic lesion of preterm infants leading to a white matter necrosis which may result in neurological handicaps and cerebral palsy. Whether hypercoagulopathy states play a role in the pathogenesis of PVL is currently unknown. The aim of this study was to investigate the prevalence of inherited thrombophilia in preterm infants with PVL and in controls.

Study Design: This study included 25 preterm infants with PVL. Brain ultrasound was first carried out 3-5 days after delivery, and repeated 3-4 weeks later. The control group included 66 term healthy infants of the same ethnic origin. Venous blood was obtained from preterm infants after the diagnosis of PVL and cord blood was obtained at delivery from the controls. Blood samples were tested for mutations of factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene.

4. HIGH PREVALENCE OF INHERITED THROMBOPHILLIA AMONG WOMEN WHO HAD PRETERM DELIVERY OR SECOND TRIMESTER ABORTION.

OBJECTIVE: To investigate the prevalence of inherited thrombophilia in women with preterm labor (PTL) at gestational age of 24-32 weeks (W) or late abortion at 17-23 (W).

STUDY DESIGN: This ongoing study includes 16 women (study group) , who had PTL (n= 12) or LA (n=4), all with singleton pregnancies. They were enrolled after delivery or abortion. Exclusion criteria were: bacterial vaginosis, history of cervical incompetence, presence of uterine anomaly. Each patients was matched for age, ethnicity and smoking status with 2 healthy women who had at least one normal pregnancy (control group n=32). All women were tested at least 2 month after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase, and prothrombin gene, and for deficiencies of protein S, protein C and antithrombin-III. All were negative for anticardiolipin antibodies and for lupus anticoagulant.

5. Monocyte-platelet aggregation in patients with pregnancy complications

Peripheral blood monocytes have been identified as key players in the evaluation of thrombotic events. The goal of this study is to identify the presence of monocyte-platelet aggregates in patients with pregnancy complications such as preeclampsia, severe IUGR or placental abruption.

6. IL-6 gene polymorphism and fibrinogen gene mutations in patients with pregnancy complications

An association between thrombosis and inflammation has recently been elucidated. In this study we investigate the presence of polymorphism in gene of IL-6, a key inflammatory cytokine, in patients with vascular pregnancy complications such as Preeclampsia, IUGR, placental abruption and IUFD. The association of this complications with mutations in the fibrinogen gene is also investigated.

7. The association between IUGR and thrombophilia

Previous reports from our department have demonstrated a significant association between pregnancy complication and thrombophilia. In this study we focus on IUGR, especially in view of recent debates in the literature. The frequency of thrombophilia in patients with IUGR is investigated and analyzed according to birth weight percentiles along with additional parameters such as placental pathology and umbilical flow.

8. Umbilical cored nucleated RBC in neonates with term polyhydramnion

Oligohydramnion has long been known as an ominous prognostic marker in IUGR and postdate pregnancies. Its significance in term AGA fetuses, on the other hand is controversial. In this study we asses the significance term oligohydramnion in AGA neonates by measuring the level of nucleated RBC-a marker of chronic hypoxemia, in their cord blood immediately after birth.

9. Red cell aggregation and the onset of spontaneous labor in term

Peripheral blood markers for the onset of spontaneous labor in term have long been seeked. In this study we investigate whether the degree of red blood cell aggregation is different before and after the onset of normal term spontaneous labor in term.

10. Red blood cell aggregation in patients with IUGR

The goal of this study is to asses whether peripheral blood red blood cell aggregation is increased in pregnant patients carrying IUGR fetuses. This is another arm of a broad study investigating the significance of red blood cell aggregation during pregnancy complications.

11. The prognostic value of high sensitivity CRP in premature contractions and imminent preterm labor

12. The association between ovarian hyperstimulation syndrome in early pregnancy and the occurrence of preeclampsia

סטודנטים 2005

1. נועם פרידמן : רמות סידן חופשי בחבל הטבור בנשים עם לידה רגיל הוניתוח קיסרי

2. מיכל לוי: הפרדות שלייה וקרישיות יתר

מחקרים שפורסמו 2005