Investigation of expression and distribution of cell-membrane complement regulatory proteins along the human respiratory tract in-vivo and in primary cultures of nasal epithelial cells using direct immunofluorescence method, avidin-biotin immunoperoxidase method and flow cytometric method.

Functional studies concerning protection of normal respiratory epithelial cells against

homologous complement.

Investigation of the effects of several pharmacological agents (ACE inhibitors,

Angiotensin II inhibitors, heparin, monophosphoril lipid A) on the isolated ischemic and non-ischemic heart.

Investigations concerning the synthesis (mRNA) and release of cytokines (TNF-alfa) and Nitric oxide from the isolated heart following ischemia and reperfusion, the effects of cytokines on the myocardium. These studies were provided with the using of immunohistochemica and ELISA methods too. Investigation of interaction between this pharmacological agents and TNF-alfa during myocardial ischemia in isolated heart and cardiomyocyte tissue culture.

Investigations concerning the effects of protamine-sulphate on the vascular wall of the human internal thoracic artery (the nitric oxide pathway). Study of cellular and intercellular mechanisms of protamin –sulphate action on isolated heart.

Investigation of vasoactive responses in different parts of the left and right human internal thoracic artery: an in-vitro study.

Clinical studies:
Dexanabinol treatment for the reduction of cognitive impairment (CI) in subjects undergoing coronary artery bypass surgery (CABG). “Pharmos”.

Double-blind multi-center study of the safety and efficacy of Parecoxib/Valdecoxib compared to placebofor the treatment of post-surgical pain in patients undergoing CABG via mid sternotomy. “Phaizer”.

IPS-05-2004 Phase ii randomized, double-blind, placebo-controlled, multi-center study to evaluate tolerability, safety, pharmakokinetiks and eficanci of intravenous INO-1001 in high-risk subjects undergoing cardiopulmonary bypass for coronary revascularization and/valve surgery. “Inotec”