1899 - Opening of Shaare Zion Hospital in Yaffo, followed by its closure, one year later, due to fierce controversy.
1914 - Laying of the corner stone of Hadassah Hospital on Nahalat Binyamin Street in Tel Aviv.
1918 - Opening of Hadassah Hospital on Nahalat Binyamin Street.
1921 - Victims of the 1920-1921 riots are treated at Hadassah Hospital.
1925 - Laying of the corner stone of Hadassah-Balfour Hospital on Balfour Street.

1926 - Opening of Hadassah-Balfour Hospital, under the management of the Hadassah Medical Organization.
1931 - The Hadassah-Balfour Hospital is now administered and managed by the Tel Aviv-Yaffo Municipality.
1933 - Assassination of Chaim Arlozoroff, Zionist leader and activist. Arlozoroff's body is brought to Hadassah- Balfour after his assassination.
1940 - Italian military planes bomb Tel Aviv, and the injured are brought to Hadassah-Balfour Hospital.
1948-1949 - Israel's War of Independence - war victims are treated at Hadassah-Balfour Hospital.
1951 - Opening of the "Kiryah" Maternity Hospital.
1953 - Construction of Ichilov Hospital continues, after delays caused by funding problems.
1961 - Opening of Ichilov Hospital in Tel Aviv.
1967 - Transfer of the municipal hospitals, Hadassah-Balfour, Ichilov and the Kiryah, to the joint authority of the municipality and the national government.
1967 - Dedication of the Sheinborn School of Nursing.
1973 - March - Naming of the Hadassah-Balfour Hospital after Y. Rokach, Mayor and former Minister of Internal Affairs.
1973 - June - The Association of Friends of Ichilov Hospital and the municipal and national governments sign an agreement to name the hospital after Elias Sourasky.
1973 - October - Victims of the Yom Kippur War are treated at Sourasky Hospital.
1978 - Victims of the terrorist attack on the coastal road receive treatment in the Hospital.
1980 -

Finance Minister and Health Minister agree to amalgamate the three municipal hospitals into The Tel Aviv Sourasky Medical Center. 
 April - Dedication of the Tel Aviv Sourasky Medical Center, transfer of the outpatient clinics from Hadar Daphne building to the new facility; dedication of the Ida Sourasky Rehabilitation Center.
1986 - Laying of the corner stone of the "Dana" Children's Hospital; establishment of the Institute for Special Medical Examinations
("Melram").
1991 -

 January - 192 victims of the Gulf War are treated at the Tel Aviv Sourasky Medical Center.
October - Dedication of "Dana" Children's Hospital.
1992 - Closing of "Rokach" Hospital and transfer of all of its departments to the Medical Center on Weizman Street.
1994 - 240 victims of the terrorist attacks on bus lines 5 and 20, and in the Dizengoff Center, are treated at the Medical Center.
March - Establishment of the Trauma Unit and the Unit of Orthopedic Oncology, for nationwide referral.

December - First kidney transplant.

1995 - Assassination of Prime Minister Yitzhak Rabin - the Prime Minister was brought to the Medical Center for treatment after being shot.
January - Opening of the Risk Management Unit.

March - Inauguration of the new Emergency Medicine Department.

April - Establishment of the Advanced Endoscopy Surgical Unit.

1996 - Ceremony naming the Yitzhak Rabin Trauma Center, in the presence of the late King Hussein, acting Prime Minister Shimon Peres and the late Leah Rabin.

1997 -

July - Transfer of the "Kiryah" Maternity Hospital and the opening of the "Lis" Maternity Hospital.

September - Ceremonial laying of the corner stone of the Arison Medical Tower, in the presence of Prime Minister Benjamin Netanyahu, and the late Ted Arison, philanthropist and donor. 
1998 -

February - Beginning of construction on Hospitalization Tower.

May - Inauguration of the Neonatal Intensive Care Unit (NICU)

June - Inauguration of the Internal Medicine H Department

September - Opening of the Shushtiel Emergency Medical Department and the Claridge Israel Emergency Rooms; commencement of construction of the Arison Medical Tower.
October - Dedication of the Wohl Magnetic Resonance Imaging (MRI) Institute; opening of Institute for Prevention of Heart Disease.

November - Opening of the new Post-Anesthesia Care Unit

1999-

April - Relocation of Blood Bank; Opening of the Department of Advanced Surgery in the Dana Hospital.

August - Relocation of the Pediatric Intensive Care Unit.

November - Inauguration of the new AIDS Center.

2000 -

January - Opening of the laboratory service center.

February - Opening of the medical community's internet initiative "Health in the Community".

May - Opening of the Clinic for Chronic Exhaustion.

June - Opening of the Clinic for Breast Imaging.

July - Opening of the southern and northern car parks.

2001 -

September - Commencement of the transfer of surgical departments to the Arison Medical Tower.

November - Launch of the Tel Aviv Sourasky Medical Center's web site.

December - Introduction of surgical MRI; opening of the entrance lobby to the hospital and the commercial center
2002 -  

January - Relocation of Surgery A and Trauma Unit to the Tower

February - Opening of the Gait and Motion Analysis Laboratory in the "Dana" Children's Hospital.

May - Transfer of Orthopedic Departments A and B to the Tower; installation of the PET-CT machine in the Isotope Institute.
December - Opening of the "natural home birth style delivery room" in the "Lis" Maternity Hospital.

2003 -

January - Relocation of Neurology, Neurosurgery, Oncology and Bone Marrow Transplants to the Hospitalization Tower.

April - Implementation of the "Tiger" system into general use.

June - Launching of the Telephone Information Center (03-6974000).
November - Preparation of the landing pad for first flights bringing in patients.
December - Relocation of the General Intensive Care Unit; receipt of two new CT machines for the Imaging division.

2004 -

January - The Radiation Institute receives new wire accelerators, that ensure accuracy and reduce length of treatment.

June - Inauguration of TARGET - a tool to measure the economic efficiency of the hospital's departments.
September - Installation of the PACS imaging system; dedication of the new synagogue.

2005 -

January - Opening of the "Avivim" Nursing and Recovery Department.
June - Upgrading of the Cardiological network; Relocation of the clinics to new and spacious premises; building two new catheterization laboratories and opening of the new Center for Cardiological Out Patient Care.

September - Tel Aviv Sourasky Medical Center wins first prize in the "Beautiful Hospital in a Beautiful Israel" competition; inauguration of the entrance gate to the hospital; placement of computerized information boards in the surgical sections that enable real-time follow-up of the patients' status.

December - Dedication of the Haim Hertzog Boulevard at the hospital's entrance; opening of the refurbished and upgraded Radiotherapy Institute.