6.1.09  
  
 
Division of Internal Medicine
Cardiology - Department
Clinical Immunology - Unit
Clincial Pharmacology - Unit
Dermatology - Department
Emergency - Department
Endocrinology, Metabolism, and Hypertension - Institute
Gastroenterology - Institute
Genetics - Institute
Geriatrics - Division
Hematology - Institute
Infectious Diseases - Unit
Internal Medicine A - Department
Internal Medicine B - Department
Internal Medicine C - Department
Internal Medicine E - Department
Internal Medicine F - Department
Internal Medicine H - Department
Internal Medicine T - Department
Internal Medicine j - Department
Internal Medicine Consultation - Department
Oncology - Institute
Bone and Soft tissue Oncology - Unit
Oncology Day Care Unit
Oncology Hospitalization Unit
Oncology Outpatient Clinic
Radiotherapy - Institute
Nephrology - Department
Neurology - Department
Pathology , Diagnostic and Research Cancer Center
Pulmonary and Allergy - Institute
Rehabilitation - Department
Rheumatology - Institute
Home Page > Division of Internal Medicine > Oncology - Institute
List of Publications:

B.1 Original Articles

1. Ron, I.G., Irith Reider, Nely Wigler, Samario Chaitchik.
Primary Spinal Epidural Non-Hodgkin’s Lymphoma - The
contribution of Nuclear Magnetic Resonance Imaging -
Therapeutic Approach and review of the literature.
Tumori 78 : 397-402, 1992.

2. I.G., Ron, N., Wigler, B., Illie, S., Chaitchik.
Small Cell Carcinoma of the gallbladder - clinical course
and response to chemotherapy.
Tumori 78: 397 - 402, 1992.

3. Merimsky ,O., Reider, Grosswasser J., Wigler, N., S. Chaitchik
Encephalopathy in Ifosfamide treated patients
Acta Neurol Scand, 1992, 0 : 1 - 5.

4. Ron, I.G., Wigler, N., Kovner ,F.,Inbar, M., Chaitchik, S.,
Combined postoperative radiotherapy and PCV - Chemotherapy
(CCNV, procarbazine and vincristine ) in managing anaplastic
astrocytoma - a report of a long term follow-up.
International Journal of Oncology 2 : 1063 - 1066, 1993.

5. Ron ,I.G., Kuten, A., Wigler, N., Fried, G., Nitezky, S., Inbar, M.,Dale ,J., Chaitchik, S.,
Classical Disseminated Kaposi’s Sarcoma in HIV negative
patients an unusual indolent subtype.
British Journal of Cancer 68 : 775 - 776, 1993.

6. Inbar, M., Merimsky, O., Wigler, N., Chaitchik, S.,
Cisplatinum related Lhermitte’s Sign.
Anti Cancer Drugs, 3 : 375 - 377, 1993.

7. Kovner, F., Merimsky,O., Hare’uveni, M., Wigler, N.,Chaitchik S.
Treatment of disease negative but mucin - like carcinoma
associated antigen- positive breast cancer patients with tamoxifen
preliminary results of a prospective controlled randomized trial
Cancer Chemotherapy Pharmacol.
1994, 35 : 80 - 83.

8. I.G., Ron, N., Wigler, O., Merimsky, M., Inbar, S., Chaitchik S.
A Phase II Trial of D-Trp-6-LHRH (Decapeptyl) in Pretreated
patients with advanced Epithelial Ovarian Cancer.
Cancer Investigation 13 (3) 272 - 275, 1995.


9. Early Breast Cancer Trialists’ Collaborative Group
( N. Wigler ):
Tamoxifen for early breast cancer: an overview of the
randomised trials.
The Lancet, vol. 351, No. 9114 Pages 1451-1467, May 1998.

10. Early Breast Cancer Trialists’ Collaborative Group
( N. Wigler ):
Polychemotherapy for early breast cancer: an overview
of the randomised trials.
The Lancet, Vol. 352, No. 9132, Pages 930-942, Sep.1998.

11. M. Gershanovich, H.A. Chaudri, D. Campos, H. Lurie et al
( N. Wigler ): ?
Letrozole, a new oral aromatase inhibitor: Randomised trial
comparing 2.5 mg daily, 0.5 mg daily and aminoglutethimide in
postmenopausal women with advanced breast cancer.
Annals of Oncology 9: 639-645, 1998.

12. F. Kovner, S. Spigel, I. Rider, I. Otremsky, I. Ron, E. Shohat,
J.M. Rabey, J. Avram, O. Merimsky, N. Wigler, S. Chaitchik,
M. Inbar:
Radiation Therapy of metastatic spinal cord compression.
Journal of Neuro-Oncology, 42: 85-92, 1999.

13. O. Merimsky, N. Wigler, Y. Schwarz, Y. Greif, A Mann,
M. Inbar:
Gemcitabine – Cisplatin Combination Chemotherapy In Metastatic Non- Small Cell Lung Cancer
Austal-Asian Journal of Cancer: Vol 1, No.1, June 2000, p. 64-68.

14. Early Breast Cancer Trialists’ Collaborative Group (N. Wigler)
Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials.
The Lancet May 2000, Vol. 355 No, 9217, Pages 1757-1770


Accepted for Publication:

15. Bar-Am, A., Ron, I.G., Kuperminc ,M., Gal, J., Kovner, F.,
Wigler, N., Inbar, M., Lessing, J.
The role of routine pelvic lymph node sampling in patients with
stage I Endometrial Carcinoma:
Second Thoughts
Acta Obstetricia et Gynecologyca Scandinavica.

16. Ron, I.G., Wigler, N., Borovik, R., Brufman,G.,Riezel,S.,Shani A.
Brenner ,J., Farbstein, H., Dale, A., Inbar, M., Brener ,H.J.,
Chaitchik, S.
CMF vs CNF as adjuvant chemotherapy for stage II lymph nodes positive Breast Cancer.
A phase III randomized multicenter study.
American Journal of Clinical Oncology.


Submitted for Publication :


17. Kovner, F., Spigel, S., Rider, I., Otremsky, I., Ron, I., Shoat, E.,
Rabai ,Y., Avram ,J., Merimsky, O., Wigler, N., Inbar, M,.
Chaitchik ,S.
Radiation therapy of metastatic spinal cord compression.
Multidisciplinary team diagnosis and treatment.
Journal of Neuro-oncology.

18. N.Wigler, S. Shina, O. Kaplan, G. Luboshits, S. Chaitchik, I. Keydar and A. Ben Baruch:
Breast carcinoma: RANTES espression as a potential marker for progressive disease.
American Journal of Clinical Pathology

19. Polychemotherapy for Early Breast Cancer: An Overview of the
Randomized Clinical Trials Using Q-TWIST.
N. Wigler
The Early Breast Cancer Trialists’ Collaborative Group Secretariat
Lancet June 2000.


B.2 Case Reports


1) Ron ,I.G., Wigler, N., Illie, B., Chaitchik, S.,
Small Cell Carcinoma of the gallbladder: clinical course and
response to chemotherapy.
Tumori 78 : 207 - 210, 1992.

2) Kovner, F., Ron, I.G., Wigler, N., Marmur, S., Chaitchik, S.
Basal Cell Carcinoma in a non - irradiated hemangioma.
Lournal of the European Academy of Dermatology and
Venerology 6: 289 - 290, 1996.


D.1 Invited papers in Scientific Meetings

1) Ron ,I.G., Wigler, N., Merimsky, O., Inbar, M., Chaitchik, S.
A phase II trial of D-Trp-6-LhRh (Decapeptyl) in pretreated
patients with advanced epithelial ovarian cancer.
4th International Symposium in GnRH Analogues in Cancer and
Human Reproduction. Geneva, Switzerland (1996) (oral
presentation).

2) Ron, I.G., Bar-Am ,A., Kupferminc, M.J., Ga,l I., Jaffa, A., Kovner, F., Wigler, N., Inbar, M., Lessing, J., Chaitchik, S.
The role of routine pelvic lymph node sampling in patients with
stage I endometrial carcinoma : Second thoughts.
The 1997 Annual Meeting of the American Radium Society.
New York, USA (1997) (poster).

D.2 Papers presented at Scientific Meetings

1) Ron, I.G., Kovner, F., Schwartz, I., Wigler, N., Inbar, M..,
Chaitchik, S.
a-interferon (INF) and DTCI in the treatment of metastatic
malignant melanoma.
The First Congress of the Israel Cancer Association, Jerusalem,
Israel (1988) (Oral presentation).

2) Wigler, N., Kovner, F., Baram, A., Avni, A., Chaitchik, S.
CAP on first line. Chemotherapy in ovarian cancer.
Binational Meeting, Germany / Israel.
Gynecologic and Obstretics Societies.
Jerusalem Hilton Hotel - Israel.
March 27-30 (1988) ( Oral presentation ).

3) Ron, I.G., Wigler, N., Rackovsky, E., Chaitchik, S.
Delta-9-Tetradihychrocannabinol as an antiemetic prophylactic
treatment to cancer patients treated with chemotherapy :
preliminary results.
The 2nd. Israeli Congress on Medical Plants, Tel Aviv, Israel
(1991) (Oral presentation).

4) Wigler, N., Ron, I.G., Borovik, R., Brufman, A., Shani, A.,
Brenner, H., Chaitchik, S.
National adjuvant chemotherapy - protocol in stage II Ca. of
Breast : CMF vs.CNF.
Pisa Symposia on Oncology, Pisa, Italy (1992) (Poster).



5) F. Kovner, S. Kreitler, M. Inbar, N. Wigler, S. Lalchuk, S. Chaitchik:


6) Wigler, N., Ron, I.G., Borovich, R., Brufman, G., Shani, A.,
Brenner, H., Chaitchik, S.
National adjuvant chemotherapy protocol in Stage II carcinoma
of the Breast. CMF vs.CNF.
The 7th European Conference on Clinical Oncology and
Nursering, Jerusalem, Israel (1993) (Poster).

7) S. Kreitler, F. Kovner, M. Inbar, N. Wigler, S. Lalchuk, S. Chaitchik:
Do Mastectomy and Lumpectomy patients differ in quality of life?
ECCO 7 ( 1993 ) ( Oral presentation ).

8) Ron, I.G., Wigler, N., Kovner, F., Inbar, M., Chaitchik, S.
Combined postoperative radiotherapy and PCV-chemotherapy
(Procarbazine, CCNU and Vincristine) in managing anaplastic
astrocytoma. A long term follow-up.
The 7th European Conference on Clinical Oncology and
Nursing, Jerusalem, Israel (1993) (Poster).

9) Wigler, N., Ron, I.G., Borovich, R., Brufman, G., Shani, A.,
Brenner, H., Chaitchik, S.
National adjuvant chemotherapy protocol in Stage II carcinoma
of the Breast. CMF vs.CNF.
The Fourth International Congress on Anti-Cancer Chemotherapy
Paris, France (1994).

10) Ron, I.G., Wigler, N., Merimsky, O., Inbar, M.J., Chaitchik, S. A phase II trial fo D-Trp-6-LhRh (Decapeptyl) in pretreated
patients with advanced epithelial ovarian cancer.
4th International Symposium on GnRH Analogues in Cancer and Human Reproduction. Geneva, Switzerland (1996)
(Oral presentation ).

11) Ron, I.G., Bar-Am, A., Kupfermine, M.J., Gal, I., Jaffa, A.,
Kovner, F., Wigler, N., Inbar, M., Lessing, J., Chaitchik, S.:
The role of routine pelvic lymph node sampling in patients with
stage I endometrial carcinoma: Second thoughts.
The 1997 Annual Meeting of the American Radium Society.
New York, USA (1997) (poster).

12) Wigler, N., Ron, I.G., Borovik, R., Brufman, A., Shani, A.,
Brenner, H., Chaitchik, S.
National adjuvant chemotherapy - protocol in stage II Ca. of
Breast : CMF vs.CNF.
21st. Annual San Antonio Breast Cancer Symposium.
(1998) ( Poster).

13) O. Merimsky, N. Wigler, J. Greif, A. Mann and M.Inbar:
Outpatient protocol with Cisplatinum and Gemcitabine for
advanced or metastatic Non small cell lung cancer.
11th. Mediterranian Congress of Chemotherapy
Tel Aviv, Israel - 18-21, October 1998 (Poster).

14) Wigler N, Merimsky O, Kovner F, Inbar M.
Routine Breast Conservation in Post-Menopausal Jewish Women:
Excellent Local And Systemic control Of the Disease.
22nd. Annual San Antonio Breast cancer Symposium
(1999) ( Poster ).

15) Pluzanska A, Jassem J, Jelic S, Gorbunova V, Mrsic-Krmpotic Z, Berzins J, Nagykalnai T, Wigler N , Renard J, et al.
A Phase III study of Doxorubicin plus Taxol (Paxlitaxel) combination versus 5-Fluorouracil plus Doxorubicin plus
Cyclophosphamide (FAC) combination as a first line treatment
for patients with metastatic breast cancer.
22nd. Annual San Antonio Breast Cancer Symposium (1999).
(Oral presentation).

16) Wigler N, Merimsky O, Kovner F, Inbar M:
Routine Breast Conservation in Post- Menopausal Jewish Women:
Excellent Local and Systemic Control of the Disease
ASCO 2000 (Poster)



D.3 Abstracts and Proceedings

1) Figer A., Loven D., Wigler N., Rath P., Walach N., Shani A.,
Kaplan E., Catane R., Cohen Y.,
Epirubicin in the treatment of advanced carcinoma of the stomach.
Proceeding ASCO Abst., 436, 1989.

2) Loven D., Figer A., Wigler N., Rath P., Walach N., Shani A.,
Sulkes A., Lev L., Kaplan E., Catane R., Cohen Y.,
Epirubicin in the treatment of advanced carcinoma of the pancreas. Submitted for ASCO 1989.
Proceeding ASCO Abst., 437.

3) Cohen Y., Loven D., Sulkes A., Wigler N., Rath P., Shani A.,
Kaplan E., Catane R.
Epirubicin in the treatment of advanced carcinoma of the Stomach or the Pancreas.
Submitted as an extended abstract to the Proceeding 16th Intl.
Congress of Chemotherapy (ICC) 1989.

4) Kovner F., Wigler N., Inbar M., Chaitchik S.
The results of combined treatment in Stage I Endometrial Cancer
Medax 1989, Jerusalem, Israel.

5) Wigler N., Ron I.G., Borovich R., Brufman G., Shani A., Brenner H., Chaitchik S.
National Adjuvant Chemotherapy Protocol in Stage II Carcinoma of the Breast. CMF Vs. CNF.
European Journal of Cancer 29 (A) (Suppl.6), S. 75: 390, 1993.

6) Ron I.G., Wigler N., Kovner F., Inbar M., Chaitchik S.
Combined postoperative radiotherapy and PVC - Chemotherapy
( Procarbazine, CCNU and Vincristine ) in managing anaplastic
Astrocytoma. A long term follow-up.
European Journal of Cancer 29 (A)(Suppl. 6), S.193:1079, 1993

7) O. Merimsky, M. Hareuveni, F. Kovner, N. Wigler, S.Chaitchik
Is there a role for tamoxifen in MCA- Positive but disease negative Breast Cancer Patients?
A Prospective randomized pilot study.
Abst. No. 19. V Symposium on Biology and clinical usefulness
on tumor markers.
Barcelona, Spain 1995.

8) O. Merimsky, N. Wigler, J. Greif, Y. Schwatz, A. Mann, and M.
Inbar:
Outpatient protocol with Cisplatin and Gemcitabine for locally advanced metastatic non-small cell lung cancer.
11th. Mediterranean Congress of Chemotherapy.
Tel-Aviv, Israel, 18-21 October, 1998.

9) O. Merimsky, M. Hareuveni, F. Kovner, N. Wigler, S. Chaitchik
Department of Oncology, Tel-Aviv Sourasky Medical Center and
Sackler School of Medicine, Tel-Aviv University, Israel.

Tamoxifen in marker-positive disease-negative
Breast Cancer patients: a prospective randomised study.
Fifth International Congress on Anti-Cancer Chemotherapy.
Paris, France ( 1995 ).


10) Ron, I.G., Wigler, N., Merimsky, O., Inbar, M.J., Chaitchik, S.:
A phase II trial of D-Trp-6-LHRH ( Decapeptyl) in pretreated
patients with advanced epithelial ovarian cancer.
Gynecological Endocrinology 10 (supp.) 138:69, 1996.



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